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Outcomes of prophylactic chemotherapy in patients with high - risk hydatidiform mole at Tu Du hospital
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The study was implemented by coauthor Tran Nhat Huy and Vo Minh Tuan.
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Objective of study is to compare the rate of gestational trophoblastic neoplasia in patients with high - risk hydatidiform mole between the groups of using and not using prophylactic chemotherapy that following up up to 6 months at Tu Du hospital.
A prospective cohort study recruited all paitents with high risk hydratidiform mole admitted Tu Du hospital from 8/2012 to 11/2012. 56 patients were undergoneprophylactic chemotherapv with MTX- FA. while the other Ì12 patients were not applied this regimen. After 6 months, the result was evaluated by comparing the rate of gestational trophoblastic neoplasia between two groups.
Study results showed that the incidence rate of gestational trophoblastic neoplasia between prophylactic chemotherapy and none groups were 25% versus 14,3%, however, the statistical significance was notfound (p>0.05. Cl 95%: 0.67 - 3.45). There was speedy regression of serum βhCG levels to undectectable in chemoprophylaxis group in a mean time of 8.5 weeks (±2.3 weeks) as against 9.5 weeks (±2.1 weeks) in group without chemoprophylaxis, (P-0. 01). There were some side effects in the MTX-FA aim noted such as nausea (39.3%), anorexia (37.5%), and dry mouth (37.5%). Applying prophylactic chemotherapy rountinely wottldn’t help to reduce the rate of gestational trophoblastic neoplasia in patients of high — risk hydatidiform mole after 6 monitoring months.
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Kim Xuyen
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